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OptGene™

OptGene™ is a novel Gene Optimizing tool that optimizes naturally occurring genes to achieve higher productivity, at the same time giving higher flexibility for protein design. The tool optimizes the genes using only the sequence information and the choice of expression system. Optgene™ allows the researcher to adapt genes and their products precisely to their specific requirements.

Production of genetically modified organisms to achieve higher productivity, disease resistance and other desirable properties is still based on naturally occurring gene sequences. Naturally occurring sequences prove futile in modern biotechnology with increased focus on safety requirement for recombinant products and at the same time higher flexibility in protein design. These gene sequences seldom meet the ever growing demand for optimized yields in heterogeneous systems.

OptGene™ achieves optimization through
• Adaptation of codon usage to that of host
• Directed Mutagenesis
• Introduction of restriction sites
• Knockout of cryptic splice sites, RNA destabilizing sequences and other undesirable sequence signals
• Removal of secondary structures in RNA
• Reduction of transcription regions in unused frames

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